Yagi et al. were the first to generate iPSCs from AD patients, harboring mutations in PSEN1 (A246E) and PSEN2 (N141I) and demonstrated increased Aβ42 secretion along with an elevated Aβ42 to Aβ40 ratio in the iPSC derived neurons as compared to those from non-AD controls. They also studied the response of the secreted Aβ42 levels to a known γ-secretase inhibitor with positive results indicating the potential of candidate drugs for AD treatment.
Another study by Kondo et al. showed intracellular accumulation of Aβ oligomers in both FAD (APP-E693D mutation) and SAD cases, inducing both endoplasmic reticulum (ER) and oxidative stress in the iPSC derived neurons. The accumulated Aβ oligomers were not proteolytically resistant and treatment of the AD neural cells with docosahexaenoic acid (DHA) resulted in alleviation of stress responses, paving the way for the development of anti-AD drugs. Learn more: cell culture models of alzheimer's disease
MJ shehorz at February 16, 2025 at 12:56am PST
Excellent weblog here! after reading, i decide to buy a sleeping bag ASAP poker88
Robin jack at February 16, 2025 at 3:51am PST
very good post, i undoubtedly really like this website, continue it cab도메인
MJ shehorz at February 16, 2025 at 11:13pm PST
Some truly nice stuff on this site, I love it. LIPOZEM REVIEW
Robin jack at February 17, 2025 at 12:15am PST
The thing i like about your blog is that you always post direct to the point info.”–”, UFAG7
MJ shehorz at February 17, 2025 at 3:55am PST
Greetings! Quick question that’s completely off topic. Do you know how to make your site mobile friendly? My weblog looks weird when viewing from my iphone. I’m trying to find a template or plugin that might be able to fix this problem. If you have any recommendations, please share. Appreciate it! Location voiture Casablanca
Robin jack at February 17, 2025 at 4:01am PST
Some truly interesting points you have written. Assisted me a lot, just what I was looking for : D. natural mounjaro ingredients
Robin jack at February 18, 2025 at 1:40am PST
But I see that the original post was published more than two years ago. Was there are any update for this elsewhere on the page? Nashville live country music
Robin jack at February 18, 2025 at 2:03am PST
Some really great info , Gladiola I found this. 호치민 이발소
Robin jack at February 18, 2025 at 11:56pm PST
Cherished could well be essentially the most needed gatherings that you saw. You might without doubt must carry out it as being pleasant as you can. In the garment to get a plants for one’s wines to your advantage people’s toast, all kinds of things wants to be in the right sequence. toto togel slot
Robin jack at February 19, 2025 at 3:30am PST
steam cleaners can clean lots of dirty clothes in a very short period of time that is why i always prefer to use them, Ice Water Hack
Robin jack at February 20, 2025 at 1:58am PST
Wow! This could be one particular of the most helpful blogs We’ve ever arrive across on this subject. Basically Magnificent. I am also an expert in this topic so I can understand your effort. Nitric Boost Ultra
Robin jack at February 21, 2025 at 10:32pm PST
I think other website owners should take this internet site as an model, very clean and wonderful user friendly design . telegram怎么注销
Robin jack at February 21, 2025 at 11:52pm PST
oh well, Alicia silverstone is matured nowadays but when she was still younger, she is the sex symbol of hollywood` Neotonics
Robin jack at February 22, 2025 at 12:28am PST
Wow! This could be one particular of the most helpful blogs We’ve ever arrive across on this subject. Basically Magnificent. I am also an expert in this topic so I can understand your effort. Puravive