Yagi et al. were the first to generate iPSCs from AD patients, harboring mutations in PSEN1 (A246E) and PSEN2 (N141I) and demonstrated increased Aβ42 secretion along with an elevated Aβ42 to Aβ40 ratio in the iPSC derived neurons as compared to those from non-AD controls. They also studied the response of the secreted Aβ42 levels to a known γ-secretase inhibitor with positive results indicating the potential of candidate drugs for AD treatment.
Another study by Kondo et al. showed intracellular accumulation of Aβ oligomers in both FAD (APP-E693D mutation) and SAD cases, inducing both endoplasmic reticulum (ER) and oxidative stress in the iPSC derived neurons. The accumulated Aβ oligomers were not proteolytically resistant and treatment of the AD neural cells with docosahexaenoic acid (DHA) resulted in alleviation of stress responses, paving the way for the development of anti-AD drugs. Learn more: cell culture models of alzheimer's disease
raheel 456 at September 03, 2025 at 11:47pm PDT
After examine a couple of of the weblog posts on your website now, and I actually like your way of blogging. I bookmarked it to my bookmark website list and shall be checking again soon. Pls try my website online as well and let me know what you think. alexistogel
Robin jack at September 03, 2025 at 11:55pm PDT
You really make it seem so easy with your presentation but I find this matter to be actually something that I think I would never understand. It seems too complex and extremely broad for me. I’m looking forward for your next post, I will try to get the hang of it! rupiah89
Robin jack at September 04, 2025 at 12:22am PDT
This plot doesn’t reveal itself; it has to be explained. Wangi4d
Robin jack at September 04, 2025 at 1:27am PDT
You might find effective specific development of any L . a . Weight loss program and each and every you’re extremely important. To begin with level is an natural misplacing during the too much weight. lose belly fat primo vs eq
Robin jack at September 04, 2025 at 1:28am PDT
Conveyancing… [...]we like to honor other sites on the web, even if they aren’t related to us, by linking to them. Below are some sites worth checking out[...]… toto