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“Psychiatry research faces a number of hurdles to the translation of preclinical discoveries into effective treatments,” said the senior chief scientist at Ace Therapeutics. “We pride ourselves on being able to create customized animal models, enabling researchers to make more sense of the complexities surrounding mental health disorders and developing efficient therapeutic adjuncts.”

Current challenges in preclinical psychiatry research At this stage, preclinical research on mental diseases has many challenges and difficulties, such as animal models are limited, pathological mechanisms are complex, drug targets are unclear, and behavioral testing methods are not advanced enough. To this end, preclinical studies on psychiatric disorders may have to create more productive animal and in vitro models and enhance biomarker discovery and validation to accelerate the discovery of novel therapeutic strategies for psychiatric diseases.

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Some of the main features of Ace Therapeutics’ animal models include: – Genetically-Engineered Models: Models that can be genetically engineered to manifest specific traits related to different psychiatric conditions such as depression, anxiety, and autism, enabling targeted research. - Robust Validation: Extensive validation studies are performed with experienced psychiatric researchers to confirm that the models accurately represent human pathophysiology.

In this context, the launch of Ace Therapeutics’ preclinical psychiatry models comes in response to increasing demand for better preclinical research tools. Utilizing leading-edge genetic modification and behavioral evaluation techniques, Ace Therapeutics offers researchers the ability to model a multitude of psychiatric disorders with unparalleled precision. The company is confident that these models can facilitate groundbreaking discoveries and accelerate the pathway from bench to bedside. Learn more about Ace Therapeutics’ Cognition Behavior Tests.

Alzheimer’s disease research relies on a variety of in vitro (cell-based) and in vivo (animal-based) models to study disease mechanisms, test potential therapies, and understand pathology. Cell-based models (e.g. organoids, iPSC-derived neurons, cell lines) are used to study molecular and cellular mechanisms of AD. Animal-based models including transgenic mouse models, rat models, and zebrafish models help study AD progression, behavior, and therapeutic interventions. Each model has strengths and limitations, and researchers often use a combination to validate findings.

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“Our custom Alzheimer's disease preclinical models are engineered to mirror the human disease phenotype more accurately, reducing translational risks in drug development,” said the business development manager at Ace Therapeutics. “By collaborating with researchers, we help optimize lead compounds and identify clinically relevant outcomes faster.”

Why Partner with Ace Therapeutics? High preclinical relevance – Models validated against human omics data for better predictivity. End-to-end support – From model selection to biomarker analysis and histopathology. Speed and efficiency – Fast turnaround times without compromising the integrity of outcome data by streamlined workflow.

With partnerships spanning top biopharma companies and academic institutions, Ace Therapeutics is at the forefront of democratizing access to precision models and AD drug development services. Its models are specifically designed to bridge the gap between basic research and therapeutic development for both familial and sporadic AD subtypes.

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Epilepsy in vitro disease models provide a controlled environment to study seizure mechanisms, neuronal hyperexcitability, and drug responses. These models utilize primary neural cell cultures, human iPSC-derived neurons, acute brain slices, and organotypic slice cultures to replicate epileptic activity and test therapeutic strategies. Techniques such as patch clamp assays, multi-electrode array (MEA) recordings, and calcium imaging enable researchers to explore biomarkers, synaptic dysfunction, and antiepileptic drug efficacy. Advancing epilepsy in vitro models enhances precision medicine, supporting innovative treatment development.

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