As a senior expert in monoclonal antibodies production and development, Creative Biolabs has established a special and professional Non-IgG Antibody Expression Systems based on our seasoned IgG isotype monoclonal antibody technologies and platforms.

Due to the limited availability of living human brain tissue, the development in elucidating the molecular and cellular pathophysiology of neuropsychiatric disorders has been hindered impeded. However, the discovery of iPSCs has offered the opportunity to study the physiology of living human neurons derived from individual patients. Learn more: stem cell differentiation

Isolation of ribosomal particles is critical for studying ribosomal composition and for analyzing factors that interact with ribosomes. As a reputable global service provider, Creative Biolabs has extensive experience in ribosome extraction and isolation experiments. We provide cost-effective services according to the different needs of customers. Learn more: Ribosome Separation and Extraction Services

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Triple Body) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-Ad fiber knob antibody are both extended with the scFv fragment from an anti-CEA antibody. Learn more: Ad fiber knob CEA Triple Body

Direct-targeting monoclonal antibodies (mAbs) approved for usage in oncology mainly belong to the immunoglobulin (Ig) G class currently. In fact, non-IgG therapeutic antibodies come of age with major progress in different kinds of human diseases, such as cancers and chronic inflammation. IgG mAb is no longer the only player in the therapeutic fields owing to antibody engineering technique, which is further driving the development of novel antibody formats. Besides, genetically modified cell-based therapies that harness the power of the immune system, together with non-IgG therapeutic antibodies, have improved cures in intractable human diseases. Learn more: IgE antibody engineering

Previous reports have provided an excellent starting point for larger prospective studies of the clinical utility of circulating tumor DNA (ctDNA) and demonstrate that ctDNA may be a useful research tool for drug development, and the study of intratumor heterogeneity and clonal evolution. As a biotechnology company standing at the forefront of the industry, Creative Biolabs is proficient in advanced technologies and the latest methods. We are confident in offering high-quality and comprehensive ctdna detection services.

The adenosine A2A receptor (A2AR) belongs to the G protein-coupled receptor (GPCR) family A or rhodopsin receptor family. Adenosine receptors include four subtypes (A1R, A2AR, A2BR, and A3R) that are activated by extracellular adenosine. A2AR and A1R are widely distributed throughout the central nervous system and surrounding, while low-density A2BR and A3R are present in the brain. Learn more: Next-IO™ A2AR Therapeutic Monoclonal Antibody Program

With years of hard working in exosome technology and engineering, Creative Biolabs has got all the necessary knowledge and technologies of exosomes. We give an introduction of the therapeutic applications of exosomes in diseases and approaches utilized for drug loading into exosomes. Learn more: exosome therapy

In order to understand human processes and behaviors, mammalian models provide the greatest insights because they share a high degree of homology with human. As it is easy to store, mouse and rat are the most important representatives. Learn more: guinea pig antibody

Point-of-care technology (POCT) diagnostic systems are tools that can rapidly lead to in vitro diagnostic (IVD) results by non-trained personnel at a patient site in varieties of locations such as the field, the home, the ambulance, or the hospital. To this day, diagnostic tests are typically operated at laboratories equipped with bench-top analyzers and managed by trained personnel. Learn more: microfluidic rapid detection

Monoclonal antibodies are versatile tools against numerous diseases ranging from cancers to series of infectious, immunological, or chronic diseases. Their high affinity and specificity towards corresponding antigens make them excellent molecular trackers for the targets in the form of antibody-based probes. Besides the expertise in antibody design and engineering, Creative Biolabs is also dedicated to the areas of high-resolution imagery, molecular tracking, and cancer diagnostics by developing customized Antibody-based Probes via the conjugation of monoclonal antibodies with various biophysical probes. Learn more: antibody labeling

This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Learn more: galc antibody

Creative Biolabs is recognized as the world leader for providing the most diverse portfolio of AI-augmented drug discovery solutions for worldwide customers. We are proud to partner with our clients on the journey of bringing novel antibody candidates to market. Learn more: antibody ai

As an incontrovertible leader in antibodies research and development, Creative Biolabs has been recognized as the leader in terms of antibody services providing. After years of foundational effort, our scientific team now provides a series of high-quality non-IgG therapeutic antibodies products and services to our valued customers. Learn more: non-IgG therapeutic antibodies for Pancreas Carcinoma

Exosomes are 30-150 nm tiny vesicles that are available to isolate and purify from plasma and other body fluids and regarded as the useful biomarker for therapeutic and diagnostic application. With years of experiences in exosome preparation, Creative Biolabs provides high-quality exosome purification services by using ultracentrifugation and microfiltration from both plasma and other body fluids with decreased co-purification of non-exosomal blood proteins, thus increasing the purification and integrity of exosomes. Learn more: exosome ultracentrifugation

Syngeneic mice-derived models could recapitulate the original disease significantly better than traditional in vitro immortalized cell line derived syngeneic models. Creative Biolabs has established dozens of syngeneic mice-derived preclinical tumor models for studying how cancer therapies perform in the presence of a functional immune system. Our models have been validated by immunohistochemistry and RNAseq, and the gene expression and mutation characteristics were confirmed. We also offer the immunological oncology analysis and immunotherapy efficacy data. Learn more: syngeneic mouse model

Plasma Glycoprotein Profiling is one of the main resources for the identification of glycoprotein biomarkers. As a leading custom service provider, Creative Biolabs has accumulated years of experience in glycoprotein profiling. Based on our first-in-class technology platforms and professional teams, we are proud to share our extensive experience with our customers all over the world in plasma glycoprotein profiling. We can offer high-quality customized services by adjusting protocols to meet even the most specific requirements.

Creative Biolabs stands out in the field of infectious disease treatment research services with its comprehensive advantages, becoming a highly trusted partner for clients. Learn more: anti parasit

Anti-glycan antibodies are antibodies to specific glycan epitopes and thus can bind specifically to glycoproteins containing these determinants. Due to the specificity of anti-glycan antibodies, they are used as essential tools for basic research. Here, Creative Biolabs gives an introduction to the application of anti-glycan antibodies in glycan/glycoprotein purification. Learn more: Glycan Antibody for Glycan Purification

As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload). A payload drug can be attached to different sites on an antibody using diverse conjugation chemistry. Multiple endogenous amino acids can serve as potential conjugation sites. However, to achieve more precisely controlled site-directed conjugations and subsequently a narrower distribution of drug-to-antibody ratio (DAR), special moieties with unique conjugation chemistries are engineered into antibody sequences in our antibody design services. Learn more: bioconjugation services

Alzheimer's disease (AD) is the most common form of dementia, a complex neurodegenerative brain disorder characterized by the progressive impairment of cognitive functions, particularly memory, thinking, language, mood, and behavioral issues.

AD is biologically defined by the presence of β-amyloid (Abeta) -containing plaques and tau-containing neurofibrillary tangles. Abeta plaques are formed by the aggregation of beta-amyloid peptides, which are fragments of a larger protein called amyloid precursor protein (APP).

Learn more: Negative Regulation of Gene Expression

Yagi et al. were the first to generate iPSCs from AD patients, harboring mutations in PSEN1 (A246E) and PSEN2 (N141I) and demonstrated increased Aβ42 secretion along with an elevated Aβ42 to Aβ40 ratio in the iPSC derived neurons as compared to those from non-AD controls. They also studied the response of the secreted Aβ42 levels to a known γ-secretase inhibitor with positive results indicating the potential of candidate drugs for AD treatment.

Another study by Kondo et al. showed intracellular accumulation of Aβ oligomers in both FAD (APP-E693D mutation) and SAD cases, inducing both endoplasmic reticulum (ER) and oxidative stress in the iPSC derived neurons. The accumulated Aβ oligomers were not proteolytically resistant and treatment of the AD neural cells with docosahexaenoic acid (DHA) resulted in alleviation of stress responses, paving the way for the development of anti-AD drugs. Learn more: cell culture models of alzheimer's disease

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Miniantibody) is a fusion protein of two scFv fragments combined with distinct specificity. One scFv of an anti-Ad fiber knob antibody variable domain is linked to another scFv of an anti-CEA antibody variable domain by a flexible hinge region. This BsAb format has the decreased size and better penetration than conventional IgGs in the clinical diagnostics and potentially therapy. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing. Learn more: Ad fiber knob CEA Miniantibody

A novel coronavirus (SARS-CoV-2) has been shown to be highly contagious and to cause many severe respiratory diseases in humans. The virus is a type of coronaviruses that has a single-stranded RNA genome, which is responsible for encoding several key proteins. With the outbreak of SARS-CoV-2 in Wuhan, Hubei Province, China, a number of in-vitro diagnostics (IVD) kits have been developed by using various PCR-based technologies, such as rRT-PCR, for screening the virus emergence in different populations. rRT-PCR has been considered as a benchmark for detecting and quantifying RNA targets and is being broadly used in clinical diagnosis. In rRT-PCR assays, an oligonucleotide probe will be designed to bind with the key sequence of SARS-CoV-2. Meanwhile, the probe will cleave when the Taq polymerase is added into this detection system. The cleavage will be detected once the fluorescent signal being released. Learn more: rRT-PCR Detect SARS-CoV-2 service

DBCO-Liposome (PEGylated) is Liposome (PEGylated) with the dibenzocyclooctyne (DBCO) group, which can react with an azide by click chemistry. The conjugation chemistry is based on the reaction of the DBCO reagent with an azide linker to form a stable triazole. Azide moiety can be on the antibody and DBCO moiety can be on liposomes and vice versa.

CD is an immune-mediated disorder initiated by the ingestion of gluten in genetically predisposed individuals. CD occurs in genetically predisposed individuals who develop an immune response to gluten. This disease is caused by an inappropriate immune response to wheat gluten, barley, and rye. This autoimmune disorder affects the small bowel and often produces symptoms of diarrhea, malabsorption, and extraintestinal symptoms. To date, the only therapy for CD is the mandatory and complete exclusion of dietary sources of grains and any food containing gluten, which is termed as a gluten-free diet (GFD). As novel therapies are being developed, complementary strategies are also being studied, such as modulation of the gut microbiome using probiotics. Learn more: probiotics and celiac disease

Immune checkpoints are regulators to enhance or moderate immune responses. Immune checkpoint mechanisms are often activated to suppress the nascent anti-tumor immune response, which leads to the development of several immune checkpoint inhibitors, such as antibodies, peptides, and small molecular drugs for cancer therapy. Combined with broad technological expertise and the latest instrumentation, Creative Biolabs is dedicated to offering a wide range of immune checkpoint development services, including antibodies, proteins, peptides, assays, small molecular drugs, and more. Our experienced team can also save you time by providing customer service to meet your specifications. Learn more: benefits of immune checkpoint inhibitors

James Parkinson revealed a detailed description of six patients with shaking palsy in 1817 and after his death, the mentioned description known as Parkinson's disease (PD), which is now the most common neurodegenerative disorder after Alzheimer's disease. The pathological hallmark of PD is the degeneration of dopaminergic neurons of the substantia nigra pars compacta (SNpc). The loss of this neuronal population results in functional imbalances in the nigrostriatal pathway, leading to lowering the level of dopamine (DA) in the striatum. Learn more: Parkinson's Disease Models

As a long-term expert in the field of macrophage polarization, Creative Biolabs has lots of scientists who are proficient at performing M1 macrophage polarization assay. Our seasoned scientists are pleased to share expertise and experience with our global clients and facilitate their meaningful macrophage polarization studies.

In the nervous system, to maintain the efficiency of axons transmitting information over long distances in the form of electrical pulses, the myelin is required to wrap around the axon. Myelin is a lipid-rich specialized membrane generated by glial cells. In the central nervous system (CNS), myelin is generated from glial cells, which are also called oligodendrocytes. Learn more: oligodendrocyte development