• The eyes are our most important sensory organs, both complex and sensitive. Many eye diseases may affect our vision, bringing terrible consequences to the way we perceive the world around us. These include harmless eye diseases such as chronic dry eye, vitreous opacities, and strabismus, as well as cataracts, glaucoma, and macular degeneration. This blog will bring helpful knowledge about glaucoma.

    What is glaucoma? Glaucoma is a group of eye diseases characterized by damage to the optic nerve, usually due to high intraocular pressure (IOP). It is often referred to as the "silent thief of sight" because it can cause irreversible vision loss without any symptoms until it's too late.

    Causes of glaucoma Glaucoma is mainly caused by the increase in intraocular pressure (eye pressure). The anterior chamber located in front of the eye is filled with clear secretion (aqueous humor) that constantly flows in and out through the anterior chamber angle. If the flow of aqueous humor is blocked and cannot be drained, it will lead to an increase in eye pressure, causing compression of the optic nerve, poor blood circulation, and damage to the optic nerve.

    People with high myopia and long-term use of corticosteroid medicines, especially eye drops, or a history of eye trauma, are more likely to develop glaucoma. In addition, systemic diseases such as migraines, Raynaud's phenomenon, low blood pressure, high cholesterol, diabetes, and others are also associated with an increased risk of glaucoma.

    Symptoms of glaucoma Glaucoma, apart from when it occurs causing a sudden rapid increase in eye pressure, other symptoms are usually only noticeable when significant damage is done to the optic nerve and/or retina. The typical symptoms include watery eyes and vision loss, such as distorted peripheral vision and narrowing of the outer visual field. Glaucoma can sometimes cause central vision loss or the appearance of colorful halos when looking at bright light sources.

    During an acute episode or glaucoma attack, eye pressure will suddenly and sharply rise. This may also be accompanied by symptoms such as red eyes, hardening of the eyeball, eye pain and headaches, nausea, vomiting, and fixed pupils (pupils do not react to light), and sudden blindness may also occur.

    Current research on glaucoma Currently, there are some great advancements in glaucoma research, including:

    "The Role of Inflammation in the Pathogenesis of Glaucoma" - This research investigates the role of inflammation in the development and progression of glaucoma, suggesting potential anti-inflammatory therapies as a treatment strategy.

    "Advances in Imaging Technologies for Glaucoma Diagnosis and Monitoring" - This study reviews recent advances in imaging technologies for the early detection and monitoring of glaucoma, highlighting the importance of early diagnosis in preventing vision loss.

    "Genetic Risk Factors for Glaucoma and Exfoliation Syndrome Identified by Genome" - This research published on PubMed Central explores the genetic risk factors associated with glaucoma, providing insights into the underlying genetic mechanisms of the disease.

    Research into glaucoma has made significant strides in recent years, bringing hope to those affected by this debilitating disease.

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  • jake miller at November 13, 2024 at 10:14pm PST

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  • Stroke is an acute cerebrovascular disease with rapid onset and high mortality. At the same time, it is difficult for unusual drugs to cross the blood brain barrier for effective treatment because its lesion site is in the brain. The time window for intravenous thrombolysis is 4.5 h after stroke, which is the best time to treat stroke. However, because of the narrow window, stroke patients often miss the best time for treatment even before the diagnosis is made.

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  • Ace Infectious provides H. pylori adhesin research services to help study the structure, adhesion sites, immune response, and potential role of H. pylori adhesins.

    Currently, H. pylori adhesins are known to adhere to small molecules (e.g., sugars) and larger ligands (e.g., proteins) of host cells. Some of these adhesins are more clearly studied. CagL interacts with the α5β1, αVβ3, αVβ5, and αVβ6 of host cells. HopQ interacts with CEACAM -1, -3, -5, and -6 of host cells. BabA, HopD, and SabA interact with mucins of host cells by blood group antigens (Leb, A- Leb, and B-Leb), sialyated Lex, and asialyated Lex. In addition, SabA also interacts with sialyated Lex and asialyated Lex of laminin. AlpA and AlpB also bind to laminin. However, the specific adhesion profiles of HorB, HomA/B/C/D, OipA, and HopZ need to be further explored. Learn more:H. pylori adhesion regulation

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  • The blood brain barrier plays an important role in stroke research. On the one hand, pathological changes in the blood-brain barrier after brain injury interact with the development of stroke pathology. On the other hand, the presence of the blood brain barrier greatly affects the efficiency of active drugs entering the brain, preventing them from acting properly at the damaged site and thus from reaching the desired effect. Therefore, the establishment of a suitable blood brain barrier model can, on the one hand, facilitate the study of the role of the blood-brain barrier in the stroke process. On the other hand, it can facilitate the development of stroke drugs and explore new methods of drug delivery targeting the brain. Ace Neuroscience provides different methods of constructing blood brain barrier models to meet the various needs of your study. Learn more:In Vivo BBB Model

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