Stroke is an acute cerebrovascular disease with rapid onset and high mortality. At the same time, it is difficult for unusual drugs to cross the blood brain barrier for effective treatment because its lesion site is in the brain. The time window for intravenous thrombolysis is 4.5 h after stroke, which is the best time to treat stroke. However, because of the narrow window, stroke patients often miss the best time for treatment even before the diagnosis is made.

Source from: stroke diagnostic technology

Ace Infectious is a specialized company focusing on Helicobacter pylori (H. pylori) research and development services. We are dedicated to all aspects of H. pylori research, including H. pylori-related gene manipulation, basic and supporting research on H. pylori, H. pylori vaccine development and pre-clinical drug development. We have a professional H. pylori research and development team and our professional strength allows us to support clients from all over the world, including government research institutions, and pharmaceutical and biotechnology companies. To know more about our services and products, please visit our details page of services and products. We look forward to cooperating with you. Learn more：H. pylori vaccine development

Ace Infectious provides H. pylori adhesin research services to help study the structure, adhesion sites, immune response, and potential role of H. pylori adhesins.

Currently, H. pylori adhesins are known to adhere to small molecules (e.g., sugars) and larger ligands (e.g., proteins) of host cells. Some of these adhesins are more clearly studied. CagL interacts with the α5β1, αVβ3, αVβ5, and αVβ6 of host cells. HopQ interacts with CEACAM -1, -3, -5, and -6 of host cells. BabA, HopD, and SabA interact with mucins of host cells by blood group antigens (Leb, A- Leb, and B-Leb), sialyated Lex, and asialyated Lex. In addition, SabA also interacts with sialyated Lex and asialyated Lex of laminin. AlpA and AlpB also bind to laminin. However, the specific adhesion profiles of HorB, HomA/B/C/D, OipA, and HopZ need to be further explored. Learn more：H. pylori adhesion regulation

The blood brain barrier plays an important role in stroke research. On the one hand, pathological changes in the blood-brain barrier after brain injury interact with the development of stroke pathology. On the other hand, the presence of the blood brain barrier greatly affects the efficiency of active drugs entering the brain, preventing them from acting properly at the damaged site and thus from reaching the desired effect. Therefore, the establishment of a suitable blood brain barrier model can, on the one hand, facilitate the study of the role of the blood-brain barrier in the stroke process. On the other hand, it can facilitate the development of stroke drugs and explore new methods of drug delivery targeting the brain. Ace Neuroscience provides different methods of constructing blood brain barrier models to meet the various needs of your study. Learn more：In Vivo BBB Model